Use metabolism to rethink the science of cancer

The Metabolic
Basis of Cancer

Faeth is a data-driven, evidence-based company with a deep mechanistic understanding of the way that dietary nutrients influence tumor growth and cancer treatment. We are fully focused on matching specific diets with tumor genotypes and treatment regimens to improve the outcomes of cancer therapy.

The differential reliance on specific nutrients between healthy and cancerous tissues creates a therapeutic window that can be exploited. By modulating nutrient levels to limit the supply of energy and building blocks that tumors require in order to grow, Faeth is able to change the way cancer cells respond to conventional treatments.

Using diet to change the systemic and tumor specific metabolic context in which therapeutic agents act has the potential to transform the efficacy of conventional cancer therapies.

The instrumentality of cancer therapies has remained largely unchanged for decades. At Faeth, we believe that the modulation of dietary nutrients will join surgery, radiotherapy, chemotherapy, and immunotherapy as the "fifth pillar" of cancer care.

Our Scientific Founders

Faeth was founded to translate breakthrough discoveries, made by world-leading cancer research laboratories, into clinical practice. Our founding team includes some of the industry’s preeminent researchers and clinicians.

Lew Cantley, Ph.D.

Director Meyer Cancer Center, Weill Cornell Medicine.
Founder: Agios (NASDAQ: AGIO), Petra, Volastra

Lew Cantley, Ph.D.

Sid Mukherjee, M.D., D.Phil.

Oncologist, Columbia University Irving Medical Center
Pulitzer Prize Winner; Time 100 Most Influential People (2011); Founder: Vor Biopharma (NASDAQ: VOR), Myeloid Therapeutics

Sid Mukherjee, M.D., D.Phil.

Hematologist and oncologist Siddhartha Mukherjee was born in New Delhi, India. He holds a BS in biology from Stanford University, a DPhil in immunology from Oxford University (where he was a Rhodes Scholar), and an MD from Harvard Medical School. He completed his internal medicine residency and an oncology fellowship at Massachusetts General Hospital. Dr. Murkherjee is an assistant professor of medicine at Columbia University Medical Center. He lives in Manhattan with his wife, artist Sarah Sze, and their two daughters.

His Pulitzer Prize-winning book, The Emperor of All Maladies: A Biography of Cancer, tells the story of cancer from its first description in an ancient Egyptian scroll to the gleaming laboratories of modern research institutions. A three-part documentary series based on the book, directed by Barak Goodman and executive produced by Ken Burns, debuts on PBS stations March 30 and continues on March 31 and April 1. The film interweaves a sweeping historical narrative with intimate stories about contemporary patients and an investigation into the latest scientific breakthroughs.

•  Medical Oncology

•  Myelodysplastic Syndrome

•  Lymphoma

•  Myeloma

•  2000 Harvard Medical School

•  Residency: 2003 Massachusetts General Hospital

•  Fellowship: 2006 Dana Farber Cancer Institute - Harvard Medical School

Karen Vousden, Ph.D.

Chief Scientist of CRUK & Group Leader, The Francis Crick Institute (UK)
Board Member, Bristol Myers Squibb

Karen Vousden, Ph.D.

Greg Hannon, Ph.D.

Director of CRUK Cambridge Institute

Greg Hannon, Ph.D.

Scott Lowe, Ph.D.

Chair of Cancer Biology & Genetics, Memorial Sloan Kettering
Founder: ORIC Pharmaceuticals (NASDAQ: ORIC)

Scott Lowe, Ph.D.

Simon Knott, Ph.D.

Assistant Professor, Biomedical Sciences
Associate Director, Center for Bioinformatics and Functional Genomics; Co-Director, Applied Computational and Genomics Technology Core, Cedars-Sinai Medical Center

Simon Knott, Ph.D.

Marcus Goncalves, M.D., Ph.D.

Physician Scientist, Assistant Professor at Weill Cornell Medical College, New York

Marcus Goncalves, M.D., Ph.D.

Ben Hopkins, Ph.D.

Assistant Professor, Icahn School of Medicine, Mount Sinai

Ben Hopkins, Ph.D.

Oliver Maddocks, Ph.D.

Senior Research Fellow, University of Glasgow
Head of Research, Faeth

Oliver Maddocks, Ph.D.

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Our Team

Anand Parikh, J.D.

CEO & Co-founder

Todd Young, M.D.

Head of Clinical Affairs

Daniel Conway

Operations Lead

Ryan Whitney

Chief of Staff

Melanie Klesse, M.S., R.D.

Dietitian

Petros Tyrakis, M.B. B.Chir., Ph.D.

Scientific Researcher

Swati Mishra, Ph.D.

Scientific Researcher

Jonathan Lindström, Ph.D.

Computational Biologist

Chris Graham

Culinary Lead

Jess Odell

Operations Associate

Select Research Papers

I
Modulating the therapeutic response of tumours to dietary serine and glycine starvation.
II
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.
III
Suppression of insulin feedback enhances the efficacy of PI3K inhibitors.
IV
Asparagine bioavailability governs metastasis in a model of breast cancer.
V
High-fructose corn syrup enhances intestinal tumor growth in mice.

Our Scientific Advisors

I
Heather Christofk, Ph.D.
Associate Director of Basic and Translational Research, UCLA Jonsson Comprehensive Cancer Center; Professor of Biological Chemistry, David Geffen School of Medicine at UCLA; Co-Director, UCLA Metabolomics Center
II
Ralph DeBerardinis, M.D., Ph.D.
Investigator, Howard Hughes Medical Institute; Chief of the Division of Genetics and Metabolism in the Department of Pediatrics, UT Southwestern Medical Center
III
Matthew Vander Heiden, M.D., Ph.D.
Associate Professor of Biology, MIT; Associate Director, Koch Institute for Integrative Cancer Research
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