Unlocking the power of metabolism to treat cancer
 

Our team of world-leading scientists have cracked the code on how to use metabolism to treat cancer. It's an entire dimension of human biology we haven't been able to leverage in treatment—until now.

Metabolic reprogramming through precise nutrient modulation

Our groundbreaking research shows that by precisely modulating nutrients through diet, we can reprogram metabolism to significantly slow cancer growth and improve the efficacy of standard treatments.

Vitamins & Co-factors

Fats

Amino Acids

Carbohydrates

Cancer-specific nutrient modulation slows tumor growth and increases survival time

 

Our preclinical research has shown that a serine and glycine restricted diet can significantly improve survival, doubling the 12-month survival rate in one model from 25% to 50%.

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Data replicated in numerous other in vivo cancer models including mouse xenograft and allograft tumor models.

  • Apc min/+ and Eμ-Myc genetically engineered mouse models of cancer

  • Diet change implemented after tumour initiation at 60-80 days of age (i.e. not from birth)

  • Intervention is diet only (i.e. without any additional therapeutic agent)

  • Maddocks et. al. (2017), Nature, 544, 372-376

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Faeth dietary intervention makes a targeted therapy more than 500% more effective

Faeth is designed to help create a foundation for many other treatments. In preclinical models, when paired with Faeth, other treatments are as much as 500% more effective.

Validated in over 10 in vivo cancer models with multiple PI3K inhibitors.

  • Pancreatic Cancer In Vivo Model

  • Syngeneic allograft tumours with mutant Kras & mutant p53

  • Hopkins et. al. (2018), Nature, 560, 499-503

Faeth makes standard treatments more effective and optimizes nutrition

When precise control of nutrition levels is combined with existing treatments, our preclinical research has shown we can stop cancer in its tracks.

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  • Pancreatic cancer and normal pancreas tissue organoids derived from multiple human subjects and grown in vitro

  • NEAAR = Non-essential amino acid restriction (removal of selected non-essential amino acids from growth medium)

  • Gem-Pac = Gemcitabine and paclitaxel


Every cancer, every patient
 

We are on a mission to develop treatments for every cancer, every patient. MetabOS is our discovery platform that combines machine learning and the metabolic genome to uncover new metabolic treatments for cancer.

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We are in clinical trials with several therapies and our pipeline is robust

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